Phosphorylation-dependent deubiquitinase OTUD3 regulates YY1 stability and promotes colorectal cancer progression

Abstract Yin Yang 1 (YY1) is a key Outdoor Chat Set transcription factor that has been implicated in the development of several malignancies.The stability of YY1 is regulated by the ubiquitin-proteasome system.The role of deubiquitinases (DUBs) and their impact on YY1 remain to be fully elucidated.In this study, we screened for ubiquitin-specific p

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Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial.

BACKGROUND:It is recommended that children aged 3 months to five years of age living in areas of seasonal transmission in the sub-Sahel should receive Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) during the malaria transmission season.The purpose of this study was to evaluate the safety of SMC with S

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